Informations générales (source: ClinicalTrials.gov)
Performance of the Variation in Arterial Lactatemia During a Spontaneous Breathing Trial (SBT) in the Prediction of Extubation Failure
Observational
Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)
septembre 2022
octobre 2025
13 mai 2026
Extubation failure (EF) is independently associated with excess mortality of critically
ill patients. To avoid EF, critically ill patients being weaned from invasive mechanical
ventilation (IMV) perform spontaneous breathing trial (SBT), which is the litmus test for
determining the ability to breathe without a ventilator.
Thus, the performance of the SBT during weaning from IMV to predict successful extubation
is crucial. The investigators hypothesize that patients with EF increase arterial lactate
concentration during SBT due to increased work of breathing and hypoxia.
The aim of this study is to evaluate the performance of variation in arterial lactate
concentration before and after SBT in predicting successful extubation in critically ill
patients.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| INSTITUT MUTUALISTE MONTSOURIS | ATCHADE Enora | 27/12/2025 07:43:17 | Contacter | ||
| AP-HP Assistance publique - Hôpitaux de Paris | 27/12/2025 07:43:18 | Contacter | |||
| AP-HP - Hôpital Beaujon | |||||
| AP-HP - Hôpital Bichat | |||||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | |||||
| AP-HP - Hôpital Saint Louis | |||||
Critères
Tous
Inclusion Criteria:
- Adult ≥ 18 years old
- Intubation and ventilation > 24 hours
- Adult ≥ 18 years old
- Intubation and ventilation > 24 hours
- Patients under guardianship or curators
- Opposition to participation in the study by the patient or family member
- Patients with tracheotomy
- Pregnant or breast-feeding women