Informations générales (source: ClinicalTrials.gov)

NCT05547633 En recrutement IDF
Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients with Exudative AMD (SINE) (SINE)
Observational
  • Sinusite
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
janvier 2023
avril 2028
05 avril 2025
An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis. Some patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis. The investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.
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Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
HOPITAL FONDATION A. DE ROTHSCHILD Raphaël LEJOYEUX En recrutement IDF 11/02/2025 15:49:34  Contacter

Critères

Tous
Inclusion Criteria:

- Age ≥ 18 years

- Patient followed and treated for at least 2 years for bilateral neovascular form of
age-related macular degeneration (AMD)

- At least one eye treated with ≥ 6 intravitreal injections during the year preceding
preinclusion

- Express consent to participate in the study

- Affiliated with or beneficiary of a social security plan


- Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all
protected persons: pregnant women, parturients, nursing mothers, persons deprived of
liberty by judicial or administrative decision, minors, and persons under legal
protection: guardianship or curatorship).

- Severe myopia (> 6 diopters)

- Patient already being treated for acute or chronic sinusitis

- History of central serous chorioretinopathy or diffuse retinal epitheliopathy