Informations générales (source: ClinicalTrials.gov)
ISIdE: Open Label, Multicentric, Single-arm Phase IIIB Trial to Evaluate the Safety and Efficacy of Sacituzumab Govitecan in Triple Negative Metastatic Breast Cancer Patients With a Biomarker Analysis
Interventional
Phase 3
UNICANCER (Voir sur ClinicalTrials)
octobre 2023
mai 2028
12 septembre 2025
ISIdE is an European, multicentric study that aims to assess the efficacy of Sacituzumab
Govitecan (SG) in locally advanced or metastatic triple-negative breast cancer where the
disease has progressed despite chemotherapy or within 6 months after the end of curative
treatments in order to:
1. evaluate the treatment efficacy in less pretreated patients.
2. identify biomarkers that could predict response or resistance to the drug.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Barbara PISTILLI | 19/06/2024 12:21:45 | Contacter | ||
Critères
Tous
Inclusion Criteria:
1. Patient must have signed a written informed consent prior to any trial specific
procedures;
Note: When the patient is unable to write to give his written consent, a trusted
person of their choice, independent from the investigator or the sponsor, can
confirm in writing the patient's consent
2. Male or female ≥ 18 years of age;
3. Patients with pathologically documented locally advanced inoperable or metastatic
triple negative breast cancer (mTNBC) whose disease has progressed on (neo)adjuvant
chemotherapy+/-immunotherapy for early TNBC or within 6 months after the end of any
systemic therapy, surgery or radiotherapy with curative intent, whatever comes last.
Note: TNBC is defined as the absence of HER2 overexpression by immunohistochemistry
(IHC) defined as IHC 0, 1+, or 2+ and fluorescence in situ hybridization [FISH]
non-amplified and estrogen receptor (ER) expression <10% and progesterone receptor
(PR) expression <10% by local pathological assessment on the most recent tissue
sample collected
4. Prior exposure to a taxane
Note: If indicated, prior therapy with ICI for patients with PD1 positive tumor and
prior treatment with PARP inhibitor for patients with gBRCAm is required
5. Measurable disease, as defined by RECIST v1.1
6. Patient must have accepted to perform on-treatment biopsies. If the physician
considers doing the biopsy on the primary tumor site because accessibility, it can
be performed only if the primary tumor site has not been previously irradiated;
7. Have metastatic site easily accessible to biopsy (with exception of bone metastasis)
Note 1: Patients with only bone metastasis will be eligible if the primary tumor is
accessible for biopsy at inclusion
Note 2: If the patient has a single measurable lesion and it is the only one that
can be biopsied, the patient cannot be included because the disease is no longer
measurable according to RECIST v1.1
8. Eastern Cooperative Oncology Group (ECOG) performance status ≤2;
9. Life expectancy ≥12 weeks;
10. Adequate haematologic and organ function
11. Negative hepatitis B surface antigen (HBsAg) test at screening (patients with a
negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test at
screening are eligible), negative hepatitis C virus (HCV) antibody test at
screening, or positive HCV antibody test followed by a negative HCV RNA test at
screening;
12. Evidence of post-menopausal status or negative pregnancy urinary test within 72
hours or serum pregnancy test within 14 days before study treatment and confirmed
prior to treatment on Cycle 1 Day 1 for female pre-menopausal patients;
13. Woman of childbearing potential and male patient must agree to use adequate
contraception for the duration of trial participation and up to 6 months after
completing treatment for women and up to 3 months for men;
14. Patient affiliated to a social security system (or equivalent);
15. Patient is willing and able to comply with the protocol for the duration of the
trial including undergoing treatment and scheduled visits, and examinations
including follow-up;
1. Patient must have signed a written informed consent prior to any trial specific
procedures;
Note: When the patient is unable to write to give his written consent, a trusted
person of their choice, independent from the investigator or the sponsor, can
confirm in writing the patient's consent
2. Male or female ≥ 18 years of age;
3. Patients with pathologically documented locally advanced inoperable or metastatic
triple negative breast cancer (mTNBC) whose disease has progressed on (neo)adjuvant
chemotherapy+/-immunotherapy for early TNBC or within 6 months after the end of any
systemic therapy, surgery or radiotherapy with curative intent, whatever comes last.
Note: TNBC is defined as the absence of HER2 overexpression by immunohistochemistry
(IHC) defined as IHC 0, 1+, or 2+ and fluorescence in situ hybridization [FISH]
non-amplified and estrogen receptor (ER) expression <10% and progesterone receptor
(PR) expression <10% by local pathological assessment on the most recent tissue
sample collected
4. Prior exposure to a taxane
Note: If indicated, prior therapy with ICI for patients with PD1 positive tumor and
prior treatment with PARP inhibitor for patients with gBRCAm is required
5. Measurable disease, as defined by RECIST v1.1
6. Patient must have accepted to perform on-treatment biopsies. If the physician
considers doing the biopsy on the primary tumor site because accessibility, it can
be performed only if the primary tumor site has not been previously irradiated;
7. Have metastatic site easily accessible to biopsy (with exception of bone metastasis)
Note 1: Patients with only bone metastasis will be eligible if the primary tumor is
accessible for biopsy at inclusion
Note 2: If the patient has a single measurable lesion and it is the only one that
can be biopsied, the patient cannot be included because the disease is no longer
measurable according to RECIST v1.1
8. Eastern Cooperative Oncology Group (ECOG) performance status ≤2;
9. Life expectancy ≥12 weeks;
10. Adequate haematologic and organ function
11. Negative hepatitis B surface antigen (HBsAg) test at screening (patients with a
negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test at
screening are eligible), negative hepatitis C virus (HCV) antibody test at
screening, or positive HCV antibody test followed by a negative HCV RNA test at
screening;
12. Evidence of post-menopausal status or negative pregnancy urinary test within 72
hours or serum pregnancy test within 14 days before study treatment and confirmed
prior to treatment on Cycle 1 Day 1 for female pre-menopausal patients;
13. Woman of childbearing potential and male patient must agree to use adequate
contraception for the duration of trial participation and up to 6 months after
completing treatment for women and up to 3 months for men;
14. Patient affiliated to a social security system (or equivalent);
15. Patient is willing and able to comply with the protocol for the duration of the
trial including undergoing treatment and scheduled visits, and examinations
including follow-up;
1. Participation in another therapeutic trial within the 30 days prior to C1D1;
2. Symptomatic, untreated, or actively progressing central nervous system (CNS)
metastases or evidence of leptomeningeal disease or clinically active spinal cord
compression. Patients with stable and asymptomatic brain metastases will be
eligible, yet the number will be capped to 15% of the overall population;
3. Previous history of cancer other than mTNBC within 5 years prior to C1D1, except of
those with a negligible risk of metastasis or death (e.g., 5-year OS rate >90%) and
treated with curative intent (e.g. carcinoma in situ of the cervix, non-melanoma
skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or stage I
uterine cancer);
4. Prior treatment with topoisomerase-1 inhibitor or with ADC containing
topoisomerase-1 inhibitor
5. Met any of the following criteria for cardiac disease:
1. Myocardial infarction or unstable angina pectoris within 6 months of enrolment.
2. History of serious ventricular arrhythmia (ie, ventricular tachycardia or
ventricular fibrillation), high-grade atrioventricular block, or other cardiac
arrhythmias requiring antiarrhythmic medications (except for atrial
fibrillation that is well controlled with antiarrhythmic medication); history
of QT interval prolongation.
3. New York Heart Association (NYHA) Class III or greater congestive heart failure
or left ventricular ejection fraction of <40%.
6. Severe uncontrolled infection requiring oral or IV antibiotics within 4 weeks prior
to C1D1;
7. Major surgical procedure within 4 weeks prior to C1D1;
8. History of severe allergic, anaphylactic, or other hypersensitivity reactions to
humanized antibodies;
9. Known hypersensitivity to the study drug, its metabolites, or formulation excipient.
10. Patients receiving concomitant anti-cancer treatments such as chemotherapy,
immunotherapy, endocrine therapy and radiotherapy;
11. Patients with unresolved toxicities from previous anticancer therapy, defined as
toxicities (other than alopecia) not yet resolved according to the common
terminology criteria for adverse events of the National Cancer Institute (NCI-CTCAE)
v5.0 grade >2
12. Treatment with systemic corticosteroids dosed at >20 mg prednisone or equivalent or
other systemic immunosuppressive medications within 2 weeks prior to C1D1;
13. Known history of testing positive for HIV or known acquired immunodeficiency
syndrome if not controlled;
14. Evidence of significant uncontrolled concomitant disease;
15. Requirement for ongoing therapy with medications that are prohibited or to be used
with caution
16. Individuals with physical or psychological conditions considered not to be
compatible with the trial;
17. Persons deprived of their liberty or under protective custody or guardianship;
18. Pregnant or breastfeeding women;
19. Patients unwilling or unable to comply with the medical follow-up required by the
trial because of geographic, familial, social, or psychological reasons.