Informations générales (source: ClinicalTrials.gov)
French Observational Study of Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in Real-World Settings (FOLLOW)
Observational [Patient Registry]
French Innovative Leukemia Organisation (Voir sur ClinicalTrials)
novembre 2022
décembre 2032
30 octobre 2024
Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in the Western
World. The disease is characterized by the accumulation and proliferation of mature,
monoclonal, CD5+ B-cells with specific immunophenotype in the peripheral blood (above
5x109/L), bone marrow and secondary lymphoid organs. Small lymphocytic leukemia (SLL) is
characterized by similar tumor cells but without increased lymphocyte count. The
management of these patients have considerably changed over the last decade. Indeed,
beyond chemo-immunotherapy, multiple targeted therapies have been approved on the basis
of phase 2 and randomized phase 3 clinical trials and have subsequently been used in
daily practice. The management of patients with SLL is similar to that of those with CLL.
In addition to therapeutic advances, the advent of new sequencing technologies has also
identified CLL genetic features that are now being incorporated in patient routine
evaluation.
We here propose to set a large-scale prospective and non-interventional study including
patients with symptomatic CLL/SLL with the aim to evaluate the real-world clinical
management of these patients and to identify the impact of treatments and therapeutic
trajectories on long-term outcome.
Etablissements
Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
---|---|---|---|---|---|
HOPITAL NOVO | VAIDA | 14/02/2025 09:03:16 | Contacter | ||
Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
AP-HP - Hôpital Avicenne | Vincent LEVY, Pr | Contact (sur clinicalTrials) | |||
AP-HP - Hôpital Cochin | Lise WILLEMS, Dr | Contact (sur clinicalTrials) | |||
AP-HP - Hôpital Jean Verdier | Laurent GILARDIN | Contact (sur clinicalTrials) | |||
CH DE VERSAILLES SITE ANDRE MIGNOT | Fatiha MERABET, Dr | Contact (sur clinicalTrials) | |||
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
AMIENS - CH Amiens Picardie Site Sud - 80054 - Amiens - France | Pierre MOREL | Contact (sur clinicalTrials) | |||
Angers Chu - 49933 - Angers - France | Aline CLAVERT, MD | Contact (sur clinicalTrials) | |||
ANNECY - CH Annecy Genevois - 74374 - Annecy - France | Stéphanie TARDY, MD | Contact (sur clinicalTrials) | |||
APHP - Hôpital Pitié Salpêtrière - Hématologie - 75651 - Paris - France | Damien ROOS-WEIL, Pr | Contact (sur clinicalTrials) | |||
AVIGNON - Centre Hospitalier - 84000 - Avignon - France | Safia CHEBREK, Dr | Contact (sur clinicalTrials) | |||
BESANCON - Hôpital Jean Minjoz - 25000 - Besançon - France | Annie BRION, MD | Contact (sur clinicalTrials) | |||
BEZIERS - Centre Hospitalier - Hématologie - 34500 - Béziers - France | Alain SAAD, Dr | Contact (sur clinicalTrials) | |||
BLOIS CH - 41000 - Blois - France | Abderrazak EL YAMANI, MD | Contact (sur clinicalTrials) | |||
Bordeaux Pessac - 33604 - Pessac - France | Marie-Sarah DILHUYDY, MD | Contact (sur clinicalTrials) | |||
BOURGOUIN-JALLIEU - CH Pierre Oudot - 38300 - Bourgoin-Jallieu - France | Florence LACHENAL | Contact (sur clinicalTrials) | |||
BREST - Hôpital Morvan - Hématologie Clinique - 29609 - Brest - France | Cristina BAGACEAN, Dr | Contact (sur clinicalTrials) | |||
CAEN - IHBN - Hématologie Clinique - 14033 - Caen - France | Baptiste MOISDON DELAPIERRE, Dr | Contact (sur clinicalTrials) | |||
CHAMBERY - CH Métropole Savoie - 73000 - Chambéry - France | Pierre FAURIE | Contact (sur clinicalTrials) | |||
Clermont-Ferrand - Chu Estaing - 63000 - Clermont-Ferrand - France | Romain Guieze, MD | Contact (sur clinicalTrials) | |||
Corbeil-Essonnes - Chsf - Corbeil-Essonnes - France | Laurence SIMON, Dr | Contact (sur clinicalTrials) | |||
Dijon Chu - 21000 - Dijon - France | Philippine ROBERT | Contact (sur clinicalTrials) | |||
Grenoble - CHUGA - Hématologie Clinique - 38043 - Grenoble - France | Sylvain CARRAS, Dr | Contact (sur clinicalTrials) | |||
GRENOBLE GHM - Institut Daniel Hollard - 38028 - Grenoble - France | Caroline ALGRIN, Dr | Contact (sur clinicalTrials) | |||
La Reunion - Gh Site Sud - Saint-pierre - France | Hugo LEGENDRE | Contact (sur clinicalTrials) | |||
La Roche Sur Yon - Chd Vendee - 85925 - La Roche-sur-Yon - France | Komivi Agbetsivi, MD | Contact (sur clinicalTrials) | |||
Le Mans CH - Le Mans - France | Kamel Laribi, Dr | Contact (sur clinicalTrials) | |||
LENS - GHT Artois - 62300 - Lens - France | Daniela ROBU | Contact (sur clinicalTrials) | |||
LIBOURNE - Hôpital Robert Boulin - 33505 - Libourne - France | Diane LARA | Contact (sur clinicalTrials) | |||
LILLE CHU - Hôpital Claude Huriez - 59037 - Lille - France | Morgane NUDEL | Contact (sur clinicalTrials) | |||
LILLE GHICL - Hôpital Saint Vincent de Paul - 59000 - Lille - France | Bénédicte HIVERT, Dr | Contact (sur clinicalTrials) | |||
LIMOGES - CHU Dupuytren 1 - 87042 - Limoges - France | Nataliya DMYTRUC | Contact (sur clinicalTrials) | |||
LYON HCL - CH Lyon Sud - 69036 - Pierre-Bénite - France | Emmanuelle FERRAND, MD | Contact (sur clinicalTrials) | |||
LYON-Centre Léon Bérard - 69008 - Lyon - France | Anne-Sophie MICHALLET, MD | Contact (sur clinicalTrials) | |||
METZ-THIONVILLE CHR- Hôpital de Mercy - Metz - France | Philippe CARRASSOU, Dr | Contact (sur clinicalTrials) | |||
MONTPELLIER - Hôpital Saint-Eloi - Hématologie Clinique - 34295 - Montpellier - France | Charles HERBAUX, Dr | Contact (sur clinicalTrials) | |||
MORLAIX - CH des pays de Morlaix - 29672 - Morlaix - France | Vincent REBIERE | Contact (sur clinicalTrials) | |||
Mulhouse - Ghrmsa - 68100 - Mulhouse - France | Bernard DRENOU, Dr | Contact (sur clinicalTrials) | |||
NANCY - CHU Brabois - 54500 - Vandœuvre-lès-Nancy - France | Pierre FEUGIER, Pr | Contact (sur clinicalTrials) | |||
NANTES - Hôpital Hôtel Dieu - Hématologie Clinique - 44093 - Nantes - France | Anne LOK, Dr | Contact (sur clinicalTrials) | |||
NIMES - CHU Caremeau - 30029 - Nîmes - France | Agathe RASCALOU-WAULTIER, Dr | Contact (sur clinicalTrials) | |||
ORLEANS - CHR - Hématologie - 44100 - Orléans - France | Omar BENBRAHIM, Dr | Contact (sur clinicalTrials) | |||
Perigueux - Ch - 24000 - Périgueux - France | Claire CALMETTES | Contact (sur clinicalTrials) | |||
PERPIGNAN - CH St Jean - Hématologie Clinique - 66000 - Perpignan - France | Laurence SANHES, Dr | Contact (sur clinicalTrials) | |||
QUIMPER - CH de Cornouaille - 29000 - Quimper - France | Kristell MAHE | Contact (sur clinicalTrials) | |||
Reims Chu - 51092 - Reims - France | Anne QUINQUENEL, Dr | Contact (sur clinicalTrials) | |||
RENNES - CHU Pontchaillou - Hématologie Clinique - 35033 - Rennes - France | Sophie DE GUIBERT, Pr | Contact (sur clinicalTrials) | |||
RENNES - Hôpital Pontchaillou - Hématologie - 35033 - Rennes - France | Marc BERNARD, Dr | Contact (sur clinicalTrials) | |||
ROUEN - Centre Henri Becquerel - Service Hématologie Clinique - 76038 - Rouen - France | Stéphane LEPRETRE, Pr | Contact (sur clinicalTrials) | |||
SAINT-BRIEUC - Hôpila Yves Le Foll - 22027 - Saint-Brieuc - France | Thomas NIVET | Contact (sur clinicalTrials) | |||
ST ETIENNE - CHU et Institut De Cancérologie Lucien Neuwirth - Saint-Priest-en-Jarez - France | FRessia HONEYMAN | Contact (sur clinicalTrials) | |||
Strasbourg - Icans - 67033 - Strasbourg - France | Luc FORNECKER, MD | Contact (sur clinicalTrials) | |||
Toulouse - IUCT Oncopole - Service d'Hématologie - 31059 - Toulouse - France | Loïc YSEBAERT, Pr | Contact (sur clinicalTrials) | |||
TOURS - Hôpital Bretonneau - 37000 - Tours - France | Caroline DARTIGEAS, MD | Contact (sur clinicalTrials) | |||
Troyes Ch - Troyes - France | Nadia ALI AMMAR, Dr | Contact (sur clinicalTrials) | |||
Vannes - Chba - Vannes - France | Antoine BONNET, Dr | Contact (sur clinicalTrials) | |||
Villejuif Igr - Villejuif - France | David GHEZ, Dr | Contact (sur clinicalTrials) |
Critères
Tous
Inclusion Criteria:
- Age ≥ 18-year old
- CLL or SLL requiring a therapeutic strategy according to iwCLL criteria or
investigator evaluation
- Patient requiring therapy for immune events (autoimmune Thrombocytopenia and
autoimmune hemolytic anemia) are eligible
- Patients who have been informed verbally and in writing about this study, and who do
not object to their data being electronically processed or subjected to data quality
control
- All consecutive patients for whom a discussion in the setting of local or regional
multidisciplinary collegial meeting (in french : réunion de concertation
pluridisciplinaire / RCP) has retained the need for starting a therapeutic strategy
(curative or palliative)
- Patients with untreated or previously treated CLL/SLL are both eligible
- Patients enrolled in a clinical trial can be included in this non-interventional
cohort study
- Patients requiring therapy for CLL/SLL-associated immune events only are also
eligible
- Age ≥ 18-year old
- CLL or SLL requiring a therapeutic strategy according to iwCLL criteria or
investigator evaluation
- Patient requiring therapy for immune events (autoimmune Thrombocytopenia and
autoimmune hemolytic anemia) are eligible
- Patients who have been informed verbally and in writing about this study, and who do
not object to their data being electronically processed or subjected to data quality
control
- All consecutive patients for whom a discussion in the setting of local or regional
multidisciplinary collegial meeting (in french : réunion de concertation
pluridisciplinaire / RCP) has retained the need for starting a therapeutic strategy
(curative or palliative)
- Patients with untreated or previously treated CLL/SLL are both eligible
- Patients enrolled in a clinical trial can be included in this non-interventional
cohort study
- Patients requiring therapy for CLL/SLL-associated immune events only are also
eligible
- Patients with no need of therapy
- Patients with asymptomatic Binet A CLL
- Patient with Richter's syndrome at inclusion
- Patient requiring immunoglobulin substitution (with no need of a more specific
therapy)