Informations générales (source: ClinicalTrials.gov)
Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy
Interventional
N/A
Assistance Publique Hopitaux De Marseille (Voir sur ClinicalTrials)
mars 2023
novembre 2027
13 août 2025
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant.
Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of
cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this
procedure presents a high risk of increasing cognitive difficulties and may even be
contraindicated for this reason alone. The difficulties found are impairments in lexical
access (anomia) and verbal memory and affect more than 60% of patients . Preoperative
cognitive rehabilitation could influence brain plasticity mechanisms but there are
currently no recommendations on this topic. In this context, the investigators have
developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They
rely on cognitive hypotheses explaining the disorders but also on models of
rehabilitation-induced neural plasticity likely to improve cognitive reserve before
surgery. The investigators hypothesize that preoperative cognitive language
rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative
language prognosis.
The primary objective is to demonstrate the protective efficacy of preoperative speech
rehabilitation on language performance postoperatively.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Anca Nica | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Département de Neurologie - Hôpital de la Pitié-Salpêtrière - APHP - Paris - France | Vincent Navarro | Contact (sur clinicalTrials) | |||
| Département de Neurophysiologie Clinique - Hôpital Roger Salengro - CHU Lille - Lille - France | Philippe Derambure | Contact (sur clinicalTrials) | |||
| Explorations Neurophysiologiques, Pôle des Neurosciences - Hôpital Pierre Paul Riquet, Purpan - Toulouse - France | Marie Denuelle | Contact (sur clinicalTrials) | |||
| Hôpital Neurologique Pierre Wertheimer- Service de Neurologie Fonctionnelle et Epileptologie - Hospices Civils Lyon - Lyon - France | Alexandra Montavont | Contact (sur clinicalTrials) | |||
| Service de Neurochirurgie -GHU Sainte-Anne - Paris - France | Elisabeth Landré | Contact (sur clinicalTrials) | |||
| Service de Neurologie - CHU de Rennes - Rennes - France | Mihai Dragos-Millia | Contact (sur clinicalTrials) | |||
| Service de Neurologie - Hôpital central -CHU Nancy - Nancy - France | Louis Maillard | Contact (sur clinicalTrials) | |||
| Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre - Strasbourg - France | Edouard Hirsch | Contact (sur clinicalTrials) | |||
| Service de Neurologie de l'Epilepsie - CHU Grenoble-Alpes - Grenoble - France | LORELLA MINOTTI | Contact (sur clinicalTrials) | |||
| Service EFSN - Hôpital Pellegrin - Bordeaux - France | Véronique Michel | Contact (sur clinicalTrials) | |||
| Service Epilptologie et Rythmologie Cérébrale - Marseille - France | Véronique Sabadell | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
1. Patient 16 years of age and older,
2. Patient whose epileptogenic area involves the temporal structures of the hemisphere
specialized for language,
3. Patient whose hemispheric specialization for language is known
4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or
resection in the temporal lobe involving the hippocampus and/or the baso-temporal
language area and whose planned surgery date is compatible with the performance of
the study,
5. Patient with a known NTB score
6. Patient who has signed an informed consent or patient whose parents or legal
guardians have signed the informed consent (or a single parent or legal guardian if
applicable)
7. Patient whose first language is French (1st language learned by the patient),
8. Patient declaring to be familiar with the use of a computer and having access to an
internet connection from home
9. Patient affiliated or benefiting from a social security system.
1. Patient 16 years of age and older,
2. Patient whose epileptogenic area involves the temporal structures of the hemisphere
specialized for language,
3. Patient whose hemispheric specialization for language is known
4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or
resection in the temporal lobe involving the hippocampus and/or the baso-temporal
language area and whose planned surgery date is compatible with the performance of
the study,
5. Patient with a known NTB score
6. Patient who has signed an informed consent or patient whose parents or legal
guardians have signed the informed consent (or a single parent or legal guardian if
applicable)
7. Patient whose first language is French (1st language learned by the patient),
8. Patient declaring to be familiar with the use of a computer and having access to an
internet connection from home
9. Patient affiliated or benefiting from a social security system.
1. Patient with a speech disorder that may impair intelligibility and compromise the
use of the interface;
2. Patient with an uncorrected hearing impairment,
3. Patients with a total intelligence quotient (IQ) <70 (assessed in the context of
care, in the year preceding the surgical procedure)
4. Patients who are pregnant, nursing, deprived of liberty, under guardianship or
curatorship.