Informations générales (source: ClinicalTrials.gov)
Prehospital Initiation of Reperfusion Therapy for Acute Ischemic Stroke: Randomized Medico-economic Evaluation of a Mobile Stroke Unit. (ASPHALT)
Interventional
N/A
Centre Hospitalier St Anne (Voir sur ClinicalTrials)
octobre 2023
juin 2027
29 juin 2024
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke
Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy
endpoints. 450 patients with confirmed acute ischemic stroke will be recruited over a
3-year period, with 3-month follow-up.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP - Hôpital Bicêtre | Christian DENIER, MD, PhD | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | ||
| AP-HP - Hôpital Bichat | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital La Pitié-Salpêtrière | Mathieu ZUBER, MD, PhD | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | ||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital Necker-Enfants Malades | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital Raymond Poincaré | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | |||
| GH PARIS SITE SAINT JOSEPH | Michaël OBADIA, MD | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | ||
| GHU PARIS PSY ET NEUROSCIENCES | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | |||
| HOPITAL FOCH | Bertrand LAPERGUE, MD | lundi 15 septembre 2025 | Contact (sur clinicalTrials) | ||
| HOPITAL FONDATION A. DE ROTHSCHILD | Pierre AMARENCO, MD | samedi 13 septembre 2025 | Contact (sur clinicalTrials) | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - hôpital Bicêtre - 94275 - Le Kremlin-Bicêtre - France | Christian DENIER, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital de la Pitié-Salpêtrière - 75013 - Paris - France | Sonia ALAMOWITCH, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital Lariboisière - 75010 - Paris - France | Mikaël MAZIGHI, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital Raymond Poincaré - 92380 - Garches - France | Sandrine Deltour, MD | Contact (sur clinicalTrials) | |||
| BSPP, Brigade des Sapeurs-Pompiers de Paris - 75017 - Paris - France | Caterina ZAMPIERI, MD | Contact (sur clinicalTrials) | |||
| GHU Paris psychiatrie & neurosciences - 75014 - Paris - France | Guillaume TURC, MD, PhD | Contact (sur clinicalTrials) | |||
| SAMU 75 de Paris - 75015 - Paris - France | Benoît VIVIEN, MD, PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Emergency call to one of the two following emergency medical service (EMS) dispatch
centers : SAMU (Service d'Aide Médicale Urgente) or BSPP (Brigade des Sapeurs
Pompiers de Paris), between 08:00 and 18:00, 5 days a week (Monday to Friday).
- Suspected acute stroke according to a dispatcher stroke identification algorithm,
adapted from the ROSIER scale
- Symptom onset-to-randomization time ≤ 6h
- Patient located within the predefined catchment area of the MSU
- MSU available at the time of the EMS call
- Informed consent (as approved by the ethics committee, informed consent will be
obtained after randomization: at the arrival of the MSU (intervention group), or at
hospital arrival (control group))
- Emergency call to one of the two following emergency medical service (EMS) dispatch
centers : SAMU (Service d'Aide Médicale Urgente) or BSPP (Brigade des Sapeurs
Pompiers de Paris), between 08:00 and 18:00, 5 days a week (Monday to Friday).
- Suspected acute stroke according to a dispatcher stroke identification algorithm,
adapted from the ROSIER scale
- Symptom onset-to-randomization time ≤ 6h
- Patient located within the predefined catchment area of the MSU
- MSU available at the time of the EMS call
- Informed consent (as approved by the ethics committee, informed consent will be
obtained after randomization: at the arrival of the MSU (intervention group), or at
hospital arrival (control group))
- Patient confined to be more than 50% of waking hours
- Unknown or uncertain onset time (e.g. wake-up stroke)
- Medical history of epilepsy
- Recent epileptic seizure (<12 hrs)
- Suspicion of pregnancy
- Parturient or breastfeeding woman
- Patient already participating in another interventional study, which could influence
the mRS at 3 months.
- Patient under guardianship or curatorship
- Patient not affiliated to French Social Security