Informations générales (source: ClinicalTrials.gov)
Prehospital Initiation of Reperfusion Therapy for Acute Ischemic Stroke: Randomized Medico-economic Evaluation of a Mobile Stroke Unit. (ASPHALT)
Interventional
N/A
Centre Hospitalier St Anne (Voir sur ClinicalTrials)
octobre 2023
juin 2027
29 juin 2024
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke
Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy
endpoints. 450 patients with confirmed acute ischemic stroke will be recruited over a
3-year period, with 3-month follow-up.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP - Hôpital Bicêtre | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| AP-HP - Hôpital Bichat | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| AP-HP - Hôpital La Pitié-Salpêtrière | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| AP-HP - Hôpital Necker-Enfants Malades | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| AP-HP - Hôpital Raymond Poincaré | TURC Guillaume | 18/04/2025 07:56:39 | Contacter | ||
| HOPITAL FOCH | BERTRAND LAPERGUE | 05/05/2025 07:12:13 | Contacter | ||
| HOPITAL FONDATION A. DE ROTHSCHILD | Michaël OBADIA | 21/06/2024 13:35:03 | Contacter | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - hôpital Bicêtre - 94275 - Le Kremlin-Bicêtre - France | Christian DENIER, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital de la Pitié-Salpêtrière - 75013 - Paris - France | Sonia ALAMOWITCH, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital Lariboisière - 75010 - Paris - France | Mikaël MAZIGHI, MD, PhD | Contact (sur clinicalTrials) | |||
| AP-HP - hôpital Raymond Poincaré - 92380 - Garches - France | Sandrine Deltour, MD | Contact (sur clinicalTrials) | |||
| BSPP, Brigade des Sapeurs-Pompiers de Paris - 75017 - Paris - France | Caterina ZAMPIERI, MD | Contact (sur clinicalTrials) | |||
| GHU Paris psychiatrie & neurosciences - 75014 - Paris - France | Guillaume TURC, MD, PhD | Contact (sur clinicalTrials) | |||
| SAMU 75 de Paris - 75015 - Paris - France | Benoît VIVIEN, MD, PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Emergency call to one of the two following emergency medical service (EMS) dispatch
centers : SAMU (Service d'Aide Médicale Urgente) or BSPP (Brigade des Sapeurs
Pompiers de Paris), between 08:00 and 18:00, 5 days a week (Monday to Friday).
- Suspected acute stroke according to a dispatcher stroke identification algorithm,
adapted from the ROSIER scale
- Symptom onset-to-randomization time ≤ 6h
- Patient located within the predefined catchment area of the MSU
- MSU available at the time of the EMS call
- Informed consent (as approved by the ethics committee, informed consent will be
obtained after randomization: at the arrival of the MSU (intervention group), or at
hospital arrival (control group))
- Emergency call to one of the two following emergency medical service (EMS) dispatch
centers : SAMU (Service d'Aide Médicale Urgente) or BSPP (Brigade des Sapeurs
Pompiers de Paris), between 08:00 and 18:00, 5 days a week (Monday to Friday).
- Suspected acute stroke according to a dispatcher stroke identification algorithm,
adapted from the ROSIER scale
- Symptom onset-to-randomization time ≤ 6h
- Patient located within the predefined catchment area of the MSU
- MSU available at the time of the EMS call
- Informed consent (as approved by the ethics committee, informed consent will be
obtained after randomization: at the arrival of the MSU (intervention group), or at
hospital arrival (control group))
- Patient confined to be more than 50% of waking hours
- Unknown or uncertain onset time (e.g. wake-up stroke)
- Medical history of epilepsy
- Recent epileptic seizure (<12 hrs)
- Suspicion of pregnancy
- Parturient or breastfeeding woman
- Patient already participating in another interventional study, which could influence
the mRS at 3 months.
- Patient under guardianship or curatorship
- Patient not affiliated to French Social Security