Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT05866991 En recrutement IDF

Titre

Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders

Type

Observational

Pathologie

Comportement déviant
Troubles mentaux
Dépression
Trouble dépressif majeur
Trouble dépressif

Phase

Promoteur

Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)

Date de début

février 2023

Date de fin

mai 2033

Dernière mise à jour

17 septembre 2025

Résumé

Despite international efforts to identify biomarkers of depression, none has been transferred to clinical practice, neither for diagnosis, evolution, nor therapeutic response. This led us to build a French national cohort (through the clinical and research network named SoPsy within the French biological psychiatry society (AFPBN) and sleep society (SFRMS)), to better identify markers of sleep and biological rhythms and validate more homogeneous subgroups of patients, but also to specify the manifestations and pathogeneses of depressive disorders.

Détail

Voir le détail Depressive disorders are a group of frequent and severe disorders that affect up to 20% of the general population. The WHO projects that depression will be the leading cause of disability by 2030. This growing public health problem is marked by a decrease in psychosocial functioning and quality of life, and is associated with a high rate of suicide. In addition, there is a significant economic impact including loss of productivity and a significant increase in the use of health care services. To date, the diagnosis of a depressive episode is based solely on clinical assessment and diagnostic criteria. Despite international efforts to identify biomarkers of depression, none of these identified biomarkers have been transferred to clinical practice, either for diagnosis, outcome or treatment prediction. Some of the difficulties and lack of replication of certain results are directly related to the nature of depressive disorders, which include a large number of very heterogeneous entities. Among the markers of interest in patients with a major depressive episode (MDE), the scientific literature has shown close links between depression and disturbances in sleep and biological rhythms. Thus, more than 90% of patients suffering from MDE have sleep complaints (PMID:28972930). Moreover, it is now well demonstrated, via epidemiological and longitudinal follow-up studies, that sleep disorders, and in particular insomnia, are both risk factors and prodromes of MDE. These sleep and rhythm abnormalities seem to persist during remission phases and appear to be risk factors for depressive recurrence. Objective abnormalities, assessed by actigraphy and polysomnography, have also been demonstrated during episodes and in subjects at risk of depression, and thus appear to be both state and trait markers of the disorder. These sleep and circadian rhythm abnormalities, in addition to being associated with depressive relapse, are associated with poor global functioning, poor quality of life and risk of metabolic syndrome. Moreover, depressive disorders encompass a very heterogeneous set of conditions, and these biomarkers seem to hold great promise for better characterising the different subtypes of disorders and for better characterising patient populations. Finally, these clinical observations make sleep and circadian rhythm abnormalities essential therapeutic targets, making it possible to propose a truly more personalised medicine in psychiatry It is therefore urgent to better characterise the different subtypes of depressive disorders and to better understand the pathogenesis and evolution of these disorders in order to have predictive markers for conversion, recurrence or therapeutic responses. The objective of identifying such markers would also ultimately be to better screen patients and to propose adapted and personalised therapeutic strategies. The constitution of a national cohort, with a fine and homogeneous characterisation between the centres, is intended to meet these objectives by assessing psychiatry, addiction, sleep and chronobiology dimensions of depressive disorders. Fermer le détail

Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
GHU PARIS PSY ET NEUROSCIENCES	GEOFFROY Pierre Alexis	En recrutement IDF	01/11/2025 07:57:03	Contacter
GHU PARIS PSY ET NEUROSCIENCES	GEOFFROY Pierre Alexis	En recrutement IDF	27/09/2025 11:26:50	Contacter
AP-HP Assistance publique - Hôpitaux de Paris		En recrutement IDF	01/11/2025 07:57:04	Contacter
	AP-HP - Hôpital Bichat
	AP-HP - Hôpital Bichat
	AP-HP - Hôpital Corentin Celton
	AP-HP - Hôpital Hôtel-Dieu
	AP-HP - Hôpital La Pitié-Salpêtrière
	AP-HP - Hôpital Lariboisiere-Fernand Widal
	AP-HP - Hôpital Lariboisiere-Fernand Widal
	AP-HP - Hôpital Louis Mourier
	AP-HP - Hôpital Louis Mourier
	AP-HP - Hôpital Robert Debré
Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Hôpital Bichat Claude Bernard - 75018 - Paris - France		En recrutement	01/11/2025 07:56:57	Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- Individuals with depressive episode characterized according to the DSM-5 criteria
regardless of the associated characteristics and comorbidities.

- Adult and child

- Affiliated to a social security

Critère de non inclusion

- don't understand or read french

- Medical condition incompatible with administration of questionnaire

- impossibility to give informed decision (subject in an emergency condition, etc.)

NCT05866991 - Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders

Informations générales
Etablissements
Critères
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