Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT05874011 En recrutement IDF

Titre

Development of a Tool to Assess Receptive Prosody in the Aftermath of a Right Stroke: Use of the Inverse Correlation Paradigm

Type

Observational

Pathologie

Accident vasculaire cérébral

Phase

Promoteur

Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)

Date de début

juillet 2024

Date de fin

janvier 2027

Dernière mise à jour

02 mars 2026

Résumé

Following a right stroke, more than half of the patients present a communication disorder. These disorders can notably concern prosody. Nevertheless, these remain relatively poorly assessed and characterized. Prosodic alterations in comprehension can result in a disruption of social cognition with potentially important consequences in terms of functional outcome and quality of life of patients. In clinical practice, the investigators do not have a tool that allows us to finely assess these disorders. Studies in healthy subjects using a processing algorithm capable of arbitrarily manipulating the pitch dynamics of recorded voices have revealed that there are stable internal representations for prosody processing. Initial pilot results show that this method can be used in a clinical context and can indeed identify and accurately measure perceptual processing deficits in prosody following a right stroke. It is necessary to continue the study of this approach with a larger number of subjects in order to have normative data and validate the diagnostic properties of this approach.

Détail

Voir le détail The aim of this project is to study impairments of speech prosodic perception using a novel data-driven psychoacoustic technique, reverse correlation. The project will, first, conduct a prospective diagnostic study on N=150 stroke patients and controls, in order to evaluate the relevance of reverse-correlation data as a marker of prosodic impairments. Second, the project will use this novel patient data for theoretical investigations such as lesion-symptom mapping, in order to better understand how prosodic processing differs between patients and controls. Finally, the project will develop a novel mobile audio-health platform to facilitate the adoption of the reverse-correlation procedure in clinical practice and to collect remote patient data to assist medical decision-making. The rationale of the reverse correlation technique is to uncover a listener's mental representation of certain prosodic patterns (e.g. the different intonation of "really?" vs "really!") by analyzing a large set of responses to random stimuli. The expected results of the project are threefold: (1) the investigators will provide a new tool able to diagnose stroke-related prosody impairments beyond existing gold standards, (2) the investigators will provide a finer characterization of symptomatological profiles in these patients and (3) the investigators will provide a new prognosis metric, implemented in a mobile application, to quantify how well a patient reacts to speech therapy day after day. The project will both further our understanding of aprosodia and provide new clinical tools to improve its diagnosis and rehabilitation. Beyond stroke, the project will also provide a case-study for the application of reverse-correlation to general speech therapy practice, benefiting patients across the whole spectrum of hearing impairments. Fermer le détail

Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
GHU PARIS PSY ET NEUROSCIENCES	VILLAIN Marie	En recrutement IDF	27/12/2025 07:33:51	Contacter
AP-HP Assistance publique - Hôpitaux de Paris		En recrutement IDF	27/12/2025 07:33:52	Contacter
	AP-HP - Hôpital La Pitié-Salpêtrière
Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS	Marie Villain			Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion criteria for patients

Patient:

- with a right supratentorial stroke (1st clinical episode of deficit) confirmed on
imaging and less than 1 year old at the time of inclusion

- right-handed

- male and female over 18 years of age

- french mother tongue

- affiliated or beneficiary of a social security plan

- free, informed and written consent signed

- Inclusion criteria for control subjects:

Subject:

- no known history of stroke

- right-handed

- over 18 years of age and matched with a case on age (plus or minus 10 years)

- french mother tongue

- affiliated or beneficiary of a social security plan

- free, informed and written consent signed

-->Exclusion Criteria: No

Critère de non inclusion

Non-inclusion criteria for patients and controls subjects

- comprehension disorders: score less than 10/15 on the BDAE (Boston Diagnostic
Aphasia Examination) command execution test

- known dementia

- illiteracy

- severe dysarthria

- psychiatric history requiring hospitalization in a specialized environment for more
than two months

- history of brain injury

- major visual or auditory perceptual disorder (hearing loss greater than 40 dB HL)

NCT05874011 - Development of a Tool to Assess Receptive Prosody in the Aftermath of a Right Stroke: Use of the Inverse Correlation Paradigm

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