Informations générales (source: ClinicalTrials.gov)
ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach (RNALS)
Observational
ZIWIG (Voir sur ClinicalTrials)
juillet 2023
juillet 2025
29 juin 2024
RNALS is a multicentre, transversal, diagnostic and non-interventional study carried out
in ALS reference centers; in order to identify a diagnostic signature for Amyotrophic
Lateral Sclerosis by analyzing of coding and non-coding RNA contained in patients saliva.
The study population consists of patients with definite or probable amyotrophic lateral
sclerosis (ALS) according to the El Escorial criteria ("ALS Subjects" group) and subjects
with no neurological history (Control group).
The control group will be made up of caregivers of patients with ALS, and caregivers of
patients with a pathology other than ALS.
The ALS patients concerned by the study already benefit from routine medical care in ALS
expert centers in France.
The patients concerned by the study will be managed without modification of the care
pathway, nor modification of the therapeutic indications, nor modification of the
diagnostic or follow-up examinations necessary according to the context, which are
carried out according to the recommendations of the HAS, CNGOF.
Etablissements
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| C.H.U. de Saint-Étienne - 42055 - Saint-Étienne - Loire - France | Jean Philippe Camdesanché, Pr | Contact (sur clinicalTrials) | |||
| CHRU Lille - 59037 - Lille - France | Véronique Danel, Dr | Contact (sur clinicalTrials) | |||
| CHU Angers - 49933 - Angers - France | Philippe Codron, Dr | Contact (sur clinicalTrials) | |||
| CHU Bordeaux - 33000 - Bordeaux - France | Gwendal Le Masson, Pr | Contact (sur clinicalTrials) | |||
| CHU Bretonneau - 37044 - Tours - France | Philippe Corcia, Pr | Contact (sur clinicalTrials) | |||
| CHU Caen - 14000 - Caen - France | Mathilde Leffliatre, Dr | Contact (sur clinicalTrials) | |||
| CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Nathalie Guy, Dr | Contact (sur clinicalTrials) | |||
| CHU de la Réunion - 97448 - Saint-Pierre - France | Ariane Choumert, Dr | Contact (sur clinicalTrials) | |||
| CHU Dupuytren - 97042 - Limoges - France | Philippe Couratier, Pr | Contact (sur clinicalTrials) | |||
| CHU Montpellier - 34295 - Montpellier - France | Elisa De La Cruz, Dr | Contact (sur clinicalTrials) | |||
| CHU Nantes - 44162 - Saint-Herblain - Loire-Atlantique - France | Claire Boutoleau Bretonière, Dr | Contact (sur clinicalTrials) | |||
| CHU Nice - 06100 - Nice - France | Marie-Hélène Soriani, Dr | Contact (sur clinicalTrials) | |||
| CHU Rennes - 35000 - Rennes - France | Paul Sauleau, Pr | Contact (sur clinicalTrials) | |||
| CHU Strasbourg - 67098 - Strasbourg - Alsace - France | Marie-Céline Fleury, Dr | Contact (sur clinicalTrials) | |||
| CHU Toulouse - 31059 - Toulouse - France | Pascal Cintas, Dr | Contact (sur clinicalTrials) | |||
| Hôpital Cavale Blanche - 29609 - Brest - France | Steeve Genestet, Dr | Contact (sur clinicalTrials) | |||
| Hôpital de la Pitié-Salpêtrière - 75013 - Paris - France | Gaëlle Bruneteau, Pr | Contact (sur clinicalTrials) | |||
| Hôpital de La Timone - 13005 - Marseille - France | Annie Verschueren, Dr | Contact (sur clinicalTrials) | |||
| Hospices Civils de Lyon - 69677 - Bron - Rhône - France | Emilien Bernar, Dr | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patient over 18 years of age,
- Patient from one of the 2 study populations:
- Diagnosis of definite or probable ALS according to El Escorial criteria
("patients ALS" group) ;
- Control group
- Patient able to carry out a mouth rinse,
- Patient affiliated to the healthcare system,
- Patient has dated and signed the consent form,
- Patient over 18 years of age,
- Patient from one of the 2 study populations:
- Diagnosis of definite or probable ALS according to El Escorial criteria
("patients ALS" group) ;
- Control group
- Patient able to carry out a mouth rinse,
- Patient affiliated to the healthcare system,
- Patient has dated and signed the consent form,
- Recent (<1 month) or ongoing bacterial or viral infection,
- Known active oral or digestive mycosis,
- Evolving, symptomatic or obvious oral pathology,
- Known pregnancy,
- Patient participating in another clinical research study,
- Patient deprived of liberty by administrative or judicial decision or under
guardianship ;
- Subject refusing to take a saliva sample;
- For the control group: direct relationship (siblings, descendants, ascendants) with
a patient included in the study;
- For control group: medical history of neurological disease (excluding migraine).