Informations générales (source: ClinicalTrials.gov)
A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) vs Epoetin Alfa for the Treatment of Anemia Due to Revised International Prognostic Scoring System (IPSS-R) Very Low, Low, or Intermediate-Risk Myelodysplastic Syndrome (MDS) in Erythropoiesis-Stimulating Agent (ESA)-Naive Participants Who Are Non-Transfusion Dependent (NTD): The "ELEMENT-MDS" Trial
Interventional
Phase 3
Bristol-Myers Squibb (Voir sur ClinicalTrials)
octobre 2023
mars 2030
02 mars 2026
The purpose of the study is to compare the efficacy and safety of Luspatercept vs epoetin
alfa in the treatment of anemia in adults due to IPSS-R very low, low, intermediate-risk
MDS in ESA-naïve participants who are non-transfusion dependent (NTD).
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Christophe WILLEKENS | 20/04/2026 10:30:06 | Contacter | ||
Critères
Tous
Inclusion Criteria
- Participant has documented diagnosis of MDS according to World Health Organization
(WHO) 2016 that meet IPSS-R classification of very low, low, or intermediate-risk
disease, (intermediate-risk of ≤ 3.5 IPSS-R score) confirmed via bone marrow
aspirate and:.
i) < 5% blasts in bone marrow and < 1% blasts in peripheral blood.
- Participant is not transfusion dependent (NTD) based on IWG2018 criteria.
- Participant is erythropoiesis-stimulating agent naive. Participants may be
randomized at the investigator's discretion if the participant received no more than
2 prior doses of epoetin alfa, epoetin alfa biosimilar, or darbepoetin alfa, with
the last dose at least 8 weeks prior to randomization.
- Participant has a baseline endogenous serum erythropoietin (sEPO) level of ≤ 500
U/L.
- Participant has symptoms of anemia:.
i) Participant records a severity score of "moderate" or greater on at least 1 PGI-S
item of fatigue, weakness, shortness of breath, or dizziness performed during the
screening period.
- Participant has a baseline Hb concentration prior to randomization of ≤ 9.5 g/dL.
The baseline Hb will be calculated using the mean of the two lowest available Hb
measurements within 16 weeks prior to randomization and must include at least one
central lab Hb reading done within the screening period (no more than 35 days before
randomization). The two Hb measurements must have been performed at least seven days
apart. Hb levels less than 21 days following RBC transfusion should not be used.
Split samples for local assessments are not required.
Exclusion Criteria
- Participant with secondary MDS (that is, MDS that is known to have arisen as the
result of chemical injury or treatment with chemotherapy and/or radiation for other
diseases).
- Participant with known history of diagnosis of AML.
- Participant with history of cerebrovascular accident (including ischemic, embolic,
and hemorrhagic cerebrovascular accident), transient ischemic attack, deep venous
thrombosis (including proximal and distal), pulmonary or arterial embolism, arterial
thrombosis, or other venous thrombosis within 6 months prior to randomization.
- Participant with a history of pure red cell aplasia and/or antibody against
erythropoietin.
- Other protocol-defined Inclusion/Exclusion criteria apply.
- Participant has documented diagnosis of MDS according to World Health Organization
(WHO) 2016 that meet IPSS-R classification of very low, low, or intermediate-risk
disease, (intermediate-risk of ≤ 3.5 IPSS-R score) confirmed via bone marrow
aspirate and:.
i) < 5% blasts in bone marrow and < 1% blasts in peripheral blood.
- Participant is not transfusion dependent (NTD) based on IWG2018 criteria.
- Participant is erythropoiesis-stimulating agent naive. Participants may be
randomized at the investigator's discretion if the participant received no more than
2 prior doses of epoetin alfa, epoetin alfa biosimilar, or darbepoetin alfa, with
the last dose at least 8 weeks prior to randomization.
- Participant has a baseline endogenous serum erythropoietin (sEPO) level of ≤ 500
U/L.
- Participant has symptoms of anemia:.
i) Participant records a severity score of "moderate" or greater on at least 1 PGI-S
item of fatigue, weakness, shortness of breath, or dizziness performed during the
screening period.
- Participant has a baseline Hb concentration prior to randomization of ≤ 9.5 g/dL.
The baseline Hb will be calculated using the mean of the two lowest available Hb
measurements within 16 weeks prior to randomization and must include at least one
central lab Hb reading done within the screening period (no more than 35 days before
randomization). The two Hb measurements must have been performed at least seven days
apart. Hb levels less than 21 days following RBC transfusion should not be used.
Split samples for local assessments are not required.
Exclusion Criteria
- Participant with secondary MDS (that is, MDS that is known to have arisen as the
result of chemical injury or treatment with chemotherapy and/or radiation for other
diseases).
- Participant with known history of diagnosis of AML.
- Participant with history of cerebrovascular accident (including ischemic, embolic,
and hemorrhagic cerebrovascular accident), transient ischemic attack, deep venous
thrombosis (including proximal and distal), pulmonary or arterial embolism, arterial
thrombosis, or other venous thrombosis within 6 months prior to randomization.
- Participant with a history of pure red cell aplasia and/or antibody against
erythropoietin.
- Other protocol-defined Inclusion/Exclusion criteria apply.