Informations générales (source: ClinicalTrials.gov)
TocilizuMab DiscontinuAtion in GIant Cell Arteritis (MAGICA)
Interventional
Phase 3
Centre Hospitalier Universitaire Dijon (Voir sur ClinicalTrials)
mai 2024
novembre 2028
05 avril 2025
Giant cell arteritis (GCA) is a large-vessel vasculitis that typically occurs in people
over the age of 50.
Corticosteroids (GC) are the cornerstone of treatment for GCA. French guidelines
recommend starting at 0.7 or 1 mg/kg/day at diagnosis, depending on the occurence of
ischemic complication(s). Then, it is recommended to gradually decrease their dose to
achieve withdrawal in 12 to 24 months.
Despite this treatment, 47% of patients relapse. Relapses are favored by rapid reduction
of corticosteroid doses and large vessel involvement at diagnosis. Fortunately, relapses
are severe in only 3.3% of cases and ischemic complications are very rare. However, this
contributes to prolonging the duration of corticosteroid treatment and thus the risk of
cortico-induced adverse events, which have not been significantly reduced in the last 20
years. The main risk factors for the development of steroid-related complications are
advanced age and cumulative steroid dose.
For this reason, the development of cortisone-sparing strategies is necessary to improve
the management of patients with GCA. Thanks to major advances in the understanding of the
pathophysiological mechanisms of GCA, new therapeutic targets have been discovered. For
example, the efficacy of tocilizumab (TCZ), an anti-IL-6 receptor monoclonal antibody,
has been demonstrated in two phase 2 trials and one phase 3 trial, leading to its
approval for the management of patients requiring rapid reduction in corticosteroid doses
and/or those relapsing repeatedly on prednisone >7.5 mg/day. In recently published US
guidelines, TCZ can even be used at diagnosis to reduce the need for corticosteroid
therapy.5 Indeed, TCZ appears to be remarkably effective in controlling GCA activity and
saves approximately 2000 mg of prednisone in cumulative dose.
At present, the place of TCZ compared to methotrexate in the therapeutic strategy is
still being evaluated, notably through the METOGiA study (PHRC-N 2017), which is being
conducted by our team. Inclusions for METOGiA ended in March 2023 with results expected
in 2025. Outside of this study, approximately 1500 patients are currently receiving TCZ
treatment for GCA (data from ROCHE-CHUGAI).
There is no doubt that TCZ treatment is effective and rather well tolerated in the
elderly population, but it generates problems that are not solved to date:
- the cost (~900€/month)
- the difficulty monitoring these patients because the biological markers usually used
to monitor GCA (CRP, ESR, fibrinogen) can no longer be measured since TCZ blocks
their production by the hepatocytes. Monitoring of disease activity therefore
requires very careful clinical examination and the use of expensive imaging tests
such as PET scans because GCA can be active despite normal ESR, CRP and fibrinogen
levels. Some studies suggest that monitoring serum IL-6 may help identify patients
with active disease, but this test is not readily available and the threshold above
which relapse should be suspected is unclear because TCZ induces an increase in
serum IL-6 levels by blocking IL-6 receptors, even in patients in remission.
- For the same reasons, infections are difficult to detect in patients treated with
TCZ.
This raises the question of how to discontinue this treatment, especially since other
treatments that do not interfere with CRP, ESR, or fibrinogen measurements are being
evaluated.
This shows that this treatment tends to be prolonged well beyond one year when the
disease is often in remission without corticosteroids. This is probably related to two
factors: 1/ the fear of relapse after treatment withdrawal; 2/ the absence of a scheme
for withdrawing TCZ.
The risk of relapse after stopping TCZ has been reported in several studies, in
particular the long-term follow-up of phase 2 and 3 trials that demonstrated the efficacy
of TCZ for the treatment of GCA. Overall, regardless of the duration of TCZ treatment,
the risk of relapse is approximately 40% 6 months after the last injection of TCZ, and
the risk of relapse is higher if the large arteries (aorta and its branches) are
involved.
Thus, although the available data are limited, it appears that tapering rather than
immediately stopping TCZ limits the risk of relapse after full withdrawal.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | Romain Paule | 05/05/2025 07:12:14 | Contacter | ||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Chu Dijon Bourgogne - 21000 - Dijon - France | Maxime SAMSON | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Written consent
- Diagnosis of GCA, defined by the following criteria:
- Age ≥50 years at diagnosis
- AND History of ESR ≥50 mm/h OR CRP ≥20 mg/L (optional criterion if temporal
artery biopsy (TAB) is positive).
- AND at least one of the following clinical criteria:
- At least one unequivocal sign of GCA (recent headache, scalp
hyperesthesia, jaw claudication, temporal artery abnormality, visual
disturbances of ischemic origin)
- Clinical sign(s) of polymyalgia rheumatica (PR)
- AND at least one of the following criteria during GCA follow-up:
- TAB consistent with the diagnosis of GCA (non-necrotizing vasculitis with
a mononuclear cell-rich inflammatory infiltrate or presence of granulomas,
with or without multinuclear giant cells)
- Evidence of temporal artery vasculitis by echo-Doppler of the temporal
arteries (unilateral or bilateral halo sign)
- Evidence of vasculitis of at least one large vessel by imaging:
- angio-CT or angio-MRI: arterial wall thickening (≥2mm for aorta; ≥1mm for
supra-aortic trunks and upper extremity arteries) and/or T1-weighted contrast.
- PET: grade 2 or 3* hypermetabolism of the wall of at least one large vessel
(aorta, supra-aortic trunks, cephalic vessels, upper extremity arteries)
(*i.e., arterial SUVmax ≥ liver SUVmax)
- GCA in remission for at least 12 weeks before randomisation (remission = absence of
symptoms due to GCA AND CRP ≤10 mg/L)
- TCZ treatment (IV or SC) or biosimilar initiated 12 to 36 months prior to
randomization
- TCZ treatment (IV or SC) or biosimilar not interrupted more than 12 weeks in the 12
months prior to randomization
- Treatment with subcutaneous TCZ (162 mg/week) or biosimilar for at least 12
consecutive weeks prior to randomization
- Treatment with corticoids stopped at least 12 weeks before randomization
(hydrocortisone treatment ≤20 mg/day is possible if given at a stable dose for the
duration of the study)
- Biological workup dating from less than 6 weeks on the day of randomization, showing
good tolerance of tocilizumab:
- AST and ALT < 1.5 x upper limit of normal (ULN)
- Hemoglobin >8 g/dL
- Platelets >100 G/L
- Neutrophils >1 G/L
- Lymphocytes >0.5 G/L
- Written consent
- Diagnosis of GCA, defined by the following criteria:
- Age ≥50 years at diagnosis
- AND History of ESR ≥50 mm/h OR CRP ≥20 mg/L (optional criterion if temporal
artery biopsy (TAB) is positive).
- AND at least one of the following clinical criteria:
- At least one unequivocal sign of GCA (recent headache, scalp
hyperesthesia, jaw claudication, temporal artery abnormality, visual
disturbances of ischemic origin)
- Clinical sign(s) of polymyalgia rheumatica (PR)
- AND at least one of the following criteria during GCA follow-up:
- TAB consistent with the diagnosis of GCA (non-necrotizing vasculitis with
a mononuclear cell-rich inflammatory infiltrate or presence of granulomas,
with or without multinuclear giant cells)
- Evidence of temporal artery vasculitis by echo-Doppler of the temporal
arteries (unilateral or bilateral halo sign)
- Evidence of vasculitis of at least one large vessel by imaging:
- angio-CT or angio-MRI: arterial wall thickening (≥2mm for aorta; ≥1mm for
supra-aortic trunks and upper extremity arteries) and/or T1-weighted contrast.
- PET: grade 2 or 3* hypermetabolism of the wall of at least one large vessel
(aorta, supra-aortic trunks, cephalic vessels, upper extremity arteries)
(*i.e., arterial SUVmax ≥ liver SUVmax)
- GCA in remission for at least 12 weeks before randomisation (remission = absence of
symptoms due to GCA AND CRP ≤10 mg/L)
- TCZ treatment (IV or SC) or biosimilar initiated 12 to 36 months prior to
randomization
- TCZ treatment (IV or SC) or biosimilar not interrupted more than 12 weeks in the 12
months prior to randomization
- Treatment with subcutaneous TCZ (162 mg/week) or biosimilar for at least 12
consecutive weeks prior to randomization
- Treatment with corticoids stopped at least 12 weeks before randomization
(hydrocortisone treatment ≤20 mg/day is possible if given at a stable dose for the
duration of the study)
- Biological workup dating from less than 6 weeks on the day of randomization, showing
good tolerance of tocilizumab:
- AST and ALT < 1.5 x upper limit of normal (ULN)
- Hemoglobin >8 g/dL
- Platelets >100 G/L
- Neutrophils >1 G/L
- Lymphocytes >0.5 G/L
- Person who is not affiliated with the national health insurance system
- Person subject to a measure of legal protection (guardianship, tutorship)
- Person subject to a court order
- Patient unable to give consent
- Person who does not speak French
- Pre-menopausal women (menopause = amenorrhea of more than 12 consecutive months)
- Uncontrolled psychotic state
- History of drug or alcohol intoxication requiring hospitalization within 12 months
prior to randomization
- Recent or scheduled surgery within 6 months of randomization
- History of organ or hematopoietic marrow transplantation (except corneal
transplantation performed at least 12 weeks prior to randomization)
- Primary or secondary immune deficiency
- Concomitant treatment with any of the following:
- Methotrexate, leflunomide, cyclosporin A, azathioprine, mycophenolate mofetil,
Janus kinase inhibitors, abatacept, secukinumab, anti-TNF-α, anakinra,
ustekinumab, or any other immunosuppressive drug within 12 weeks prior to
randomization
- Rituximab or other anti-CD20 agent within 1 year prior to randomization
- Cyclophosphamide in the year prior to randomization
- History of long-term corticosteroid therapy for conditions other than GCA or PPR.
(NB: dermocorticoids, inhaled corticosteroids, and corticosteroid joint
infiltrations are allowed during the study)
- Patient who has previously received ≥3 courses of oral corticosteroids for a disease
other than GCA or RRP within 6 months prior to randomization
- Ongoing anti-tuberculosis treatment at the time of randomization
- Infections:
- Current viral hepatitis B or C
- Ongoing HIV infection
- Severe infection requiring hospitalization within 30 days prior to
randomization
- Any unstable or poorly controlled condition or disease, acute or chronic, not
related to GCA, and considered a contraindication to tocilizumab therapy in the
opinion of the investigator
- Neoplasia < 5 years, (except cervical cancer in situ and skin carcinoma, except
melanoma, with R0 resection)