Informations générales (source: ClinicalTrials.gov)
Patient-reported Outcomes in Status Epilepticus Requiring Intensive Care Unit Management. A Multicenter Longitudinal Cohort Study (POSEIDON2)
Observational
Versailles Hospital (Voir sur ClinicalTrials)
mai 2024
juillet 2026
06 novembre 2024
Status epilepticus (SE) is a common life-threatening neurological emergency in which
prolonged or multiple closely spaced seizures can result in long-term impairments. SE
remains associated with considerable mortality and morbidity, with little progress over
the last three decades. The proportion of patients who die in the hospital is about 20%
overall and 40% in patients with refractory SE. Morbidity is more difficult to evaluate,
as adverse effects of SE are often difficult to differentiate from those attributed to
the cause of SE. Our experience suggests that nearly 50% of patients may experience
long-term functional impairments. The precise description of the consequences of these
functional impairments and their impact on quality of life after SE requiring intensive
care management has been little studied. Indeed, if cognitive, physical and mental
impairments are now identified in the populations of patients who required intensive care
under the term postresuscitation syndrome (PICS), neuronal lesions consecutive to the SE
itselfor to its cause could be responsible for these different functional alterations.
Thus, the following have been described: (i) cognitive disorders in the areas of
attention, executive functions and verbal fluency, visual and working memory disorders,
but also spatio-temporal disorders; (ii) physical disorders such as the so-called
post-resuscitation polyneuromyopathy; and (iii) mental disorders such as anxiety
disorders, depressive states or those related to post-traumatic stress.
Assessment and characterization of patient-reported outcomes is essential to complement
the holistic assessment of clinically relevant outcomes from the patient's perspective.
The POSEIDON study was a cross-sectional collection of PROs and HR-QOL components, and
associated with patient functional outcomes, in those who required ICU management for
status epilepticus. We propose here to continue the description of potential alterations
after a subsequent ME, namely a longitudinal study (POSEIDON 2) which will also include
the evaluation of patient-reported experience (PREMS) and the measurement of family
burden.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | Nicolas MAYENCO CARDENAL | 05/05/2025 07:12:14 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - Hôpital Beaujon | Charles BERNARD, MD | Contact (sur clinicalTrials) | |||
| CH DE VERSAILLES SITE ANDRE MIGNOT | Gwenaëlle JACQ, RN,MSc,PhDc | Contact (sur clinicalTrials) | |||
| GH PARIS SITE SAINT JOSEPH | Cedric BRUEL, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CH d'Angoulême - Angoulême - France | David SCHNELL, MD | Contact (sur clinicalTrials) | |||
| CH de Béthune - Béthune - France | Ghada SBOUI, MD | Contact (sur clinicalTrials) | |||
| CH de La Rochelle - La Rochelle - France | Olivier LESUEUR, MD | Contact (sur clinicalTrials) | |||
| CH de Roanne - Roanne - France | Pascal BEURET, MD | Contact (sur clinicalTrials) | |||
| CHU de Dijon - Dijon - France | Jean-Pierre QUENOT, MD | Contact (sur clinicalTrials) | |||
| CHU de Grenoble - Grenoble - France | Florian SIGAUD, MD | Contact (sur clinicalTrials) | |||
| CHU de Nantes - Nantes - France | Jean-Baptiste LASCARROU, MD | Contact (sur clinicalTrials) | |||
| CHU Tours - Tours - France | Paër-Sélim ABBACK, MD | Contact (sur clinicalTrials) | |||
| Hôpital Foch - Suresnes - France | Nicolas MAYENCO-CARDENAL, MD | Contact (sur clinicalTrials) | |||
| Hôpital Henri Mondor - Créteil - France | Nicolas MONGARDON, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Adults 18 years old or older
- Patients previously included in the ICTAL registry (Status Epilepticus cohort
NCT03457831)
- Survivors after ICU management for Status Epilepticus More than 3 months and less
than 5 years after ICU discharge
- Adults 18 years old or older
- Patients previously included in the ICTAL registry (Status Epilepticus cohort
NCT03457831)
- Survivors after ICU management for Status Epilepticus More than 3 months and less
than 5 years after ICU discharge
- Legal guardianship
- Opposition to participate
- Unread and unwritten French language
- Patient not affiliated to a Social Security system