Informations générales (source: ClinicalTrials.gov)
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Observational
Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)
juin 2024
octobre 2025
15 septembre 2025
Severe trauma remains the leading cause of death in people under 50, and is associated
with high morbidity, including severe disability, with a substantial socio-economic
impact. Secondary to trauma, multiple mechanisms (inflammatory, ischemic, oxidative,
etc.) setting in rapidly, leads to organ failure, one of the three first cause of death.
Vascular damage, with vasoplegia, renal damage, with acute kidney injury (AKI), and
pulmonary damage, with acute respiratory distress syndrome (ARDS), are the most
frequently observed but all organs can be affected whatever the type of trauma. For these
reasons, identifying the pathophysiological pathways involved in organ failure induced by
severe trauma is a major step towards limiting the morbidity and mortality induced by
trauma, and proposing therapies to prevent them.
Because of the variability of lesions in these patients, and the multiplicity of pathways
activated, the mechanisms involved and their causality with organ failure following
severe trauma, are still poorly understood. Given their frequency and importance in terms
of morbidity and mortality, the investigators decided to take a particular interest in
the mechanisms leading to renal and pulmonary injury. The investigators' hypothesis is
that the study of urinary and blood markers not performed as part of clinical routine
would provide a better understanding of the pathophysiological mechanisms leading to
organ failure secondary to severe trauma, and more specifically to renal and pulmonary
injuries. With TRAUMATEC study, the investigators will explore mechanisms leading to AKI
and ARDS through blood and urine samples of 60 severe trauma patients sampled over the
first 48 hours after ICU admission and a reference of 20 healthy volunteers.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HIA PERCY | WERNER Marie | 13/12/2025 07:40:31 | Contacter | ||
| AP-HP Assistance publique - Hôpitaux de Paris | 13/12/2025 07:40:31 | Contacter | |||
| AP-HP - Hôpital Bicêtre | |||||
Critères
Tous
Inclusion Criteria:
Trauma patients :
- Adult patients (age ≥ 18 years)
- Patient admitted for suspected severe trauma (1 Vittel criteria)
- Injury Severity Score ≥ 9
- Health insurance
- Written consent obtained from the patient or trusted support person / family member
/ close friend, or inclusion in an emergency situation and written consent obtained
from the patient (trusted support person / family member / close friend if
necessary) as soon as possible (article L1122-1-2 of the CSP).
Healthy volunteers :
- Adult patients (≥ 18 years)
- Affiliated with health insurance
- Written informed consent́
- Patient respecting matching
Trauma patients :
- Adult patients (age ≥ 18 years)
- Patient admitted for suspected severe trauma (1 Vittel criteria)
- Injury Severity Score ≥ 9
- Health insurance
- Written consent obtained from the patient or trusted support person / family member
/ close friend, or inclusion in an emergency situation and written consent obtained
from the patient (trusted support person / family member / close friend if
necessary) as soon as possible (article L1122-1-2 of the CSP).
Healthy volunteers :
- Adult patients (≥ 18 years)
- Affiliated with health insurance
- Written informed consent́
- Patient respecting matching
Trauma patients :
- Pregnant patient
- Minor patient
- Adult under guardianship, curatorship or safeguard of justice
- Patient under Aide Médicale d'État
- Chronic renal failure on dialysis
- Chronic respiratory disease
- Patient with chronic cardiac insufficiency
- Systemic inflammatory disease
Healthy volunteers :
- Pregnant patient
- Minor patient
- Adult under guardianship, curatorship or safeguard of justice
- Patient under Aide Médicale d'État
- Patient with chronic renal failure on dialysis
- Chronic respiratory disease
- Patient with chronic cardiac insufficiency
- Systemic inflammatory disease