Informations générales (source: ClinicalTrials.gov)
Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study. The Crush or Crash Study. (CoC)
Observational
Nantes University Hospital (Voir sur ClinicalTrials)
novembre 2023
mai 2025
29 juin 2024
There is a great heterogeneity in the practice of rapid sequence induction in the
operating room in the world. There are no recent data assessing the rate of
implementation of the latest French formalized expert recommendations in clinical
practice. In addition, the modalities for the management of haemodynamic disorders,
particularly hypotensive disorders, during rapid sequence induction are not described in
these recommendations, although these are frequent events with a non-zero morbidity
mortality potential.
The goal of this prospective, observational, multicenter, anesthetic study is to describe
the clinical practice of French anesthesiologists regarding the prevention of severe
hemodynamic disorders during rapid sequence anesthetic induction in adult patients.
The primary outcome measure is the occurrence of a major haemodynamic disorder defined by
a MBP ≤ 50 mmHg (or ≤ 40% of the reference value) and/or ≥ 110 mmHg and/or the occurrence
of sustained arrhythmia not present at induction and/or cardiac arrest within the first
10 minutes after induction of anesthesia.
The clinical practices of pre-oxygenation, induction and intubation of French
anesthesiologists and compliance with the formalized expert recommendations of 2017 and
2018 will also be studied secondarily. The elements for the prevention of gastric fluid
inhalation, the organization and equipment used, the anesthetic and non-anesthetic drugs
used, the clinical and paraclinical neurological and cardio-respiratory parameters and
the nature of the complications following anaesthetic induction will be collected up to
the 10th post-induction minute.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP - Hôpital Bichat | Aurélie Gouel | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital La Pitié-Salpêtrière | Dimitri Margetis | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital Lariboisiere-Fernand Widal | Sophie Dagois | Contact (sur clinicalTrials) | |||
| AP-HP - Hôpital Tenon | Gauthier Hamon | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Clinical - Angoulême - Soyaux - France | Gianluca Caragliano | Contact (sur clinicalTrials) | |||
| Centre Hospitalier Intercommunal - Castres - France | Mathilde Vernet | Contact (sur clinicalTrials) | |||
| Centre hospitalier intercommunal - Toulon - France | Sophie Prieur | Contact (sur clinicalTrials) | |||
| Centre Léon Bérard - Lyon - France | Grégoire Wallon | Contact (sur clinicalTrials) | |||
| CHD Vendée - La Roche-sur-Yon - France | Mathieu Oudot | Contact (sur clinicalTrials) | |||
| Clinique de la Sagesse - Rennes - France | Stéphanie Chevalier | Contact (sur clinicalTrials) | |||
| Clinique de la Sauvegarde - Lyon - France | Olivier Desebbe | Contact (sur clinicalTrials) | |||
| Clinique de Villeneuve Saint Georges - Villeneuve-Saint-Georges - France | Virginie Trehel-Tursis | Contact (sur clinicalTrials) | |||
| Clinique Rhéna - Strasbourg - France | Nadège Erb | Contact (sur clinicalTrials) | |||
| Clinique Victor Pauchet - Amiens - France | Pierre Huette | Contact (sur clinicalTrials) | |||
| Groupe Hospitalier Seclin Carvin - Seclin - France | Alexandre Turbelin | Contact (sur clinicalTrials) | |||
| Hôpital Privé Arras les Bonnettes - Arras - France | Matthias Garrot | Contact (sur clinicalTrials) | |||
| Hôpitaux du Leman - Thonon-les-Bains - France | Caroline Gauthier | Contact (sur clinicalTrials) | |||
| Hospital - Arcachon - France | Jeremy Allary | Contact (sur clinicalTrials) | |||
| Hospital - Armentières - France | Lucile Debaecker | Contact (sur clinicalTrials) | |||
| Hospital - Lorient - France | Seamus Thierry | Contact (sur clinicalTrials) | |||
| Hospital - Montargis - France | Ahiab Alnumier | Contact (sur clinicalTrials) | |||
| Hospital - Mont-de-Marsan - France | Andersen Ramorasata | Contact (sur clinicalTrials) | |||
| Hospital - Rodez - France | Julie Delmas | Contact (sur clinicalTrials) | |||
| Hospital - Saint-Malo - France | Guillaume Allo | Contact (sur clinicalTrials) | |||
| Hospital - Valenciennes - France | Fanny Cointre | Contact (sur clinicalTrials) | |||
| Institut Gustave Roussy - Villejuif - France | Jamie Elmawieh | Contact (sur clinicalTrials) | |||
| Saint Joseph Saint Luc Hospital - Lyon - France | Mathieu Fontaine | Contact (sur clinicalTrials) | |||
| University Hopital - Edouard Herriot - Lyon - France | Emma Aka | Contact (sur clinicalTrials) | |||
| University Hospital - Brest - France | Anais Caillard | Contact (sur clinicalTrials) | |||
| University Hospital - Caen - France | Valentin Lefrancois | Contact (sur clinicalTrials) | |||
| University Hospital - Clermont-Ferrand - France | Thomas Godet | Contact (sur clinicalTrials) | |||
| University Hospital - Hautepierre - Strasbourg - France | Julie Gaudefroy | Contact (sur clinicalTrials) | |||
| University Hospital - Lille - France | Victor Lestrade | Contact (sur clinicalTrials) | |||
| University Hospital - Nantes - France | Hugo Ingles | Contact (sur clinicalTrials) | |||
| University Hospital - Pasteur - Nice - France | Victor Gridel | Contact (sur clinicalTrials) | |||
| University Hospital - Poitiers - France | Quentin Saint Genis | Contact (sur clinicalTrials) | |||
| University Hospital - Rangueil - Toulouse - France | Vincent Pey | Contact (sur clinicalTrials) | |||
| University Hospital - Sud - Lyon - France | Marc Bouchet | Contact (sur clinicalTrials) | |||
| University Hospital La Réunion - Site Nord - Saint-Denis - France | Laurent Thiltges | Contact (sur clinicalTrials) | |||
| University Hospital La Réunion - site Ouest - Saint-Paul - France | Alexis Carpentier | Contact (sur clinicalTrials) | |||
| Yves Le Foll Hospital - Saint brieuc - France | Lauren Daviet | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Age ≥ 18 years' old
- Procedure requiring general anesthesia with oro or nasotracheal intubation
- Anesthetic management with indication of rapid sequence induction
- No objection after oral and written information to the patient
- Age ≥ 18 years' old
- Procedure requiring general anesthesia with oro or nasotracheal intubation
- Anesthetic management with indication of rapid sequence induction
- No objection after oral and written information to the patient
- Age < 18 years' old
- Impossible intubation planned
- Preoperative respiratory distress (SpO2 < 90% in ambient air)
- Preoperative shock (MBP≤ 65 mmHg or vasopressive amines)
- Preoperative coma defined by a Glasgow score ≤ 12/15
- Patient in cardiopulmonary arrest
- Patients under guardianship or curatorship