Informations générales (source: ClinicalTrials.gov)
A First-In-Human (FIH) Phase I/II Open-label, Multicentre, Dose Escalation and Expansion Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors Including Non-small Cell Lung Cancer (NSCLC) Harboring Mesenchymal-Epithelial Transition (MET) Alterations
Interventional
Phase 1/Phase 2
Pierre Fabre Medicament (Voir sur ClinicalTrials)
octobre 2024
octobre 2032
03 juillet 2025
The goal of this clinical trial is to investigate the safety, the activity of VERT-002
(PFL-002), and the optimal safe dose to be used, in participants with solid tumors
including non-small cell lung cancer.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| APHP de Marseille - Hôpital Nord - 13915 - Marseille - France | Contact (sur clinicalTrials) | ||||
| Institut de Cancerologie de Ouest (ICO) - Saint-Herblain - 44805 - Saint-Herblain - France | Contact (sur clinicalTrials) | ||||
| Institut Universitaire du Cancer de Toulouse - Oncopole - 31100 - Toulouse - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
1. Part 1: histological confirmation of relapsed and/or refractory locally advanced or
metastatic solid tumor for which no standard of care treatment is available.
2. Part 2: histological confirmation of locally advanced or metastatic NSCLC Stage
IIIB/C or IV (American Joint Commission on Cancer [AJCC] 8th edition) in
participants who are not eligible for or should have received available standard of
care therapies including curative intent surgery, chemoradiation, radiotherapy or
systemic therapy.
3. Part 1: presence of at least one of the following MET alterations based on local
documentation of blood or archived tissue results:
- METex14 mutation
- MET kinase domain activating gene mutations (e.g. H1094L/R/Y, D1228H/N/V,
Y1230A/C/D/H)
- MET amplification
4. Part 2-a: presence of METex14 mutation (based on local documentation of blood or
archived tissue results) and for Part 2-b presence of at least one of the following
MET alterations: METex14 mutation (based on local documentation of blood or archived
tissue results), de novo MET amplification (based on local documentation of archived
tissue results). Confirmation after enrollment in the trial will be performed by
central testing from an archival tumor biopsy sample (either tissue block or at
least 15 serial cut unstained slides of 5 μm, at least 20% tumor content). In case
no archival biopsy is available for central testing, the patient must be willing to
have a fresh tumor biopsy sample collected and the tumor biopsy should be deemed
safe and feasible by the investigator.
5. Part 2: at least one measurable target lesion according to RECIST v1.1.
6. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
7. Part 1: participants may have received MET Tyrosine Kinase Inhibitor (TKI) as part
of previous treatment, regardless of the line of therapy (first or second line), and
regardless of the MET TKI being combined or not. Note: crizotinib will be considered
a MET TKI.
8. Part 2: a maximum of 3 prior lines of systemic therapies.
9. Adequate hematologic function.
10. Adequate hepatic function.
11. Adequate renal function.
12. Albumin ≥ 3 g/dL.
13. Adequate coagulation function.
14. Adequate cardiac function.
15. Female participants of childbearing potential must have a negative highly sensitive
serum β-HCG test performed within 7 days prior to the first dose of VERT-002 and a
negative urine pregnancy test performed at C1D1 prior to the first dose of VERT-002.
16. Male participants/partners with female spouse/partners of childbearing potential
must agree to take appropriate precautions to avoid fathering a child.
NOTE: Other protocol defined inclusion criteria may apply.
1. Part 1: histological confirmation of relapsed and/or refractory locally advanced or
metastatic solid tumor for which no standard of care treatment is available.
2. Part 2: histological confirmation of locally advanced or metastatic NSCLC Stage
IIIB/C or IV (American Joint Commission on Cancer [AJCC] 8th edition) in
participants who are not eligible for or should have received available standard of
care therapies including curative intent surgery, chemoradiation, radiotherapy or
systemic therapy.
3. Part 1: presence of at least one of the following MET alterations based on local
documentation of blood or archived tissue results:
- METex14 mutation
- MET kinase domain activating gene mutations (e.g. H1094L/R/Y, D1228H/N/V,
Y1230A/C/D/H)
- MET amplification
4. Part 2-a: presence of METex14 mutation (based on local documentation of blood or
archived tissue results) and for Part 2-b presence of at least one of the following
MET alterations: METex14 mutation (based on local documentation of blood or archived
tissue results), de novo MET amplification (based on local documentation of archived
tissue results). Confirmation after enrollment in the trial will be performed by
central testing from an archival tumor biopsy sample (either tissue block or at
least 15 serial cut unstained slides of 5 μm, at least 20% tumor content). In case
no archival biopsy is available for central testing, the patient must be willing to
have a fresh tumor biopsy sample collected and the tumor biopsy should be deemed
safe and feasible by the investigator.
5. Part 2: at least one measurable target lesion according to RECIST v1.1.
6. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
7. Part 1: participants may have received MET Tyrosine Kinase Inhibitor (TKI) as part
of previous treatment, regardless of the line of therapy (first or second line), and
regardless of the MET TKI being combined or not. Note: crizotinib will be considered
a MET TKI.
8. Part 2: a maximum of 3 prior lines of systemic therapies.
9. Adequate hematologic function.
10. Adequate hepatic function.
11. Adequate renal function.
12. Albumin ≥ 3 g/dL.
13. Adequate coagulation function.
14. Adequate cardiac function.
15. Female participants of childbearing potential must have a negative highly sensitive
serum β-HCG test performed within 7 days prior to the first dose of VERT-002 and a
negative urine pregnancy test performed at C1D1 prior to the first dose of VERT-002.
16. Male participants/partners with female spouse/partners of childbearing potential
must agree to take appropriate precautions to avoid fathering a child.
NOTE: Other protocol defined inclusion criteria may apply.
1. Part 2: Documented evidence by local testing of targetable oncogene driver
mutations.
2. History of a primary malignancy other than the cancer under trial (as defined for
Parts 1 and 2) with the exception of:
- Participants with a previous malignancy who completed their anticancer
treatment at least 2 years before signing informed consent and with no evidence
of residual disease from the prior malignancy at screening.
- Malignancies with a negligible risk of metastasis or death (i.e. 5-year overall
survival rate > 90%) that are adequately treated.
3. Uncontrolled Central Nervous System (CNS) metastases or spinal cord compression that
are associated with progressive neurological symptoms or require increasing doses of
corticosteroids to control the CNS disease.
4. History of hypersensitivity to active or inactive ingredients of VERT-002, or drugs
with a similar chemical structure or from a similar class.
5. Active, bacterial, fungal, or viral infection, within 2 weeks prior to the first
dose of VERT-002 (C1D1).
6. Positive SARs-CoV-2 or variants of SARs-CoV2 test within 2 weeks prior to first dose
administration of VERT-002 (C1D1) or with suspected infection with SARs-CoV-2 or
variants of SARs-CoV-2 and confirmation pending.
7. Impaired cardiovascular function or clinically significant cardiovascular disease
(either active or within 6 months prior to signing main informed consent).
8. Uncontrolled intercurrent illness including, but not limited to psychiatric illness
or social situation that would limit compliance with trial requirements.
9. Past medical history of Interstitial Lung Disease (ILD), drug induced ILD, radiation
pneumonitis that requires steroid treatment, or any evidence of clinically active
ILD.
10. Women who are pregnant or breastfeeding.
11. Prior anticancer therapy:
- MET TKI within 7 days prior to the first dose of VERT-002,
- Any other systemic anticancer therapy within 28 days or 5 half-lives of the
anticancer therapy whichever is the shortest, but with a minimum of 14 days
interval, prior to the first dose of VERT-002 (C1D1),
- Radiotherapy to a large field or including a vital organ (including whole brain
radiotherapy or stereotactic radiosurgery to brain) within 14 days prior to the
first dose of VERT-002 (C1D1).
12. Live attenuated vaccine within 28 days prior to the first dose of VERT-002 (C1D1).
13. Any toxicities from prior therapy with NCI- CTCAE Grade > 1 at the time of the first
dose administration of VERT-002 (C1D1). Exceptions include any grade alopecia,
fatigue and peripheral neuropathy with a grade ≤ 2.
14. Major surgical procedure within 14 days of the first dose of VERT-002 (C1D1).
15. Participation in a clinical trial with administration of an investigational drug
within 5 half- lives plus 14 days of the investigational drug, prior to the first
dose of VERT-002 (C1D1).
NOTE: Other protocol defined exclusion criteria may apply.