Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT06820866 En recrutement IDF

Titre

Non-invasive Diagnosis of Idiopathic Nephrotic Syndromes : DNI-SNI

Type

Observational

Pathologie

Néphrose
Néphrose lipoïdique
Syndrome néphrotique
Syndrome

Phase

Promoteur

Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)

Date de début

avril 2025

Date de fin

août 2027

Dernière mise à jour

16 septembre 2025

Résumé

Renal biopsy (RB) is the reference diagnostic procedure for Idiopathic Nephrotic Syndrome (INS). It is an invasive procedure, particularly risky during the acute phase of nephrotic syndrome when anticoagulation therapy is required. By identifying serum antibodies that allow for the non-invasive diagnosis of the main differential diagnoses of INS, (Membranous Nephropathy), the development of a non-invasive diagnostic tool for INS could help reduce the morbidity associated with the invasive renal biopsy procedure, minimizing the risk of incorrect diagnosis. We developed a diagnostic score, the SNIT, from routine clinical and biological variables to allow INS diagnoses in patients for whom detection of blood antibodies of Membranous Nephropathy were negative. The main goal of this study is to validate this diagnosis score in a prospective study, to allow INS diagnosis without renal biopsy.

Détail

Voir le détail Medical management will not be altered by the protocol, and patients will be treated according to the practices of each center. The investigator will offer participation in the study to all eligible consecutive patients in their center. They will provide an information sheet and answer any questions the patient may have. After obtaining the patient's non-opposition, the following clinical and biological data will be collected: (Age, sex, medical and surgical history, BMI at admission, systolic and diastolic blood pressure at admission, presence of lower limb edema, CBC, blood electrolyte levels, urea, creatinine, albumin levels, urinary electrolytes, proteinuria, albuminuria, urine culture, antinuclear antibodies, serum protein electrophoresis, serum protein immunofixation, complement fractions C3 and C4, lipid profile). The SNIT calculation will be performed automatically in the CRF from the variables it comprises, but will not be visible to the investigator. As part of patient care, patients will be followed up one month after inclusion. During this visit, the evolving biological data (creatinine, albumin levels, proteinuria, albuminuria) and the treatment administered will be collected from the patient's medical records. The final diagnosis will be collected as soon as it is available (within a maximum of 4 months for the completion and reporting of the histopathological results). Histological data will be collected from the report of the pathologist who examined the renal biopsy (available in the medical record). (In the case of INS: presence or absence of segmental and focal hyalinosis lesions, percentage of fibrosis). The objectives of this study will be : 1. Evaluate the diagnostic performance of SNIT compared to renal biopsy (reference examination) for the diagnosis of Idiopathic Nephrotic Syndrome (INS) 2. Evaluate the other diagnostic parameters of the SNIT test. 3. Evaluate the avoidable costs 4. Evaluate the theoretical risks of a misdiagnosis of INS (through diagnostic delay and its consequences, as well as the risk of unnecessary corticosteroid treatment). Duration of participant involvement and study duration: The inclusion period will be 24 months. The follow-up period for participants will be a maximum of 4 months (until the histological diagnosis is returned). Therefore, the total duration of the research will be a maximum of 28 months. Fermer le détail

Etablissements

Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données
CHI ANDRE GREGOIRE	LAHENS Alexandre	En recrutement IDF	01/11/2025 08:02:37	Contacter
HOPITAL FOCH	Alexandre HERTIG	En recrutement IDF	03/11/2025 08:27:01	Contacter
AP-HP Assistance publique - Hôpitaux de Paris		En recrutement IDF	01/11/2025 08:02:38	Contacter
	AP-HP - Hôpital Bichat
	AP-HP - Hôpital Europeen Georges Pompidou
	AP-HP - Hôpital Henri Mondor-Albert Chenevier
	AP-HP - Hôpital Lariboisiere-Fernand Widal
	AP-HP - Hôpital Necker-Enfants Malades
	AP-HP - Hôpital Saint Louis
	AP-HP - Hôpital Tenon

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- Patients aged 18 years and older

- Hospitalized for a first episode of nephrotic syndrome (proteinuria greater than
3g/g and albumin level < 30g/L)

- Negative anti-PLA2r antibodies in the blood

- Requirement for a renal biopsy for diagnostic purposes

Critère de non inclusion

- Patients with known lupus nephropathy (prior to the current episode)

- Patients with known IgA nephropathy (prior to the current episode)

NCT06820866 - Non-invasive Diagnosis of Idiopathic Nephrotic Syndromes : DNI-SNI

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