Informations générales (source: ClinicalTrials.gov)
Observation of the Response to Ovulation Induction on the Day of Intrauterine Insemination and Correlation Between Progesterone Level and Pregnancy Rate (OVUL-IIU) (OVUL-IIU)
Observational
Centre Hospitalier Intercommunal Creteil (Voir sur ClinicalTrials)
octobre 2024
octobre 2025
27 juin 2025
Intrauterine inseminations (IUI) are a commonly used technique in assisted reproductive
technology (ART) to help women conceive, whether within a couple or as single
individuals. However, national success rates remain modest, with an average live birth
rate of 10% per cycle, which leads many ART centers to favor in vitro fertilization (IVF)
as a more effective option.
Nevertheless, IUI retains several advantages: it is less invasive, less expensive, and,
when appropriately indicated, can achieve satisfactory outcomes.
Guidelines exist for ovarian stimulation protocols prior to IUI, aimed at optimizing the
chances of success. So far, no clear superiority has been demonstrated between
pharmacological ovulation triggering and spontaneous ovulation. However, accurate timing
of insemination in relation to ovulation is recognized as a key factor for success.
Very few studies have focused on the response to ovulation triggering, and none have
explored a correlation with clinical pregnancy rates.
Yet, monitoring of the luteal phase and response to ovulation triggering is a common
practice in ART, particularly in the context of frozen embryo transfers (FET), suggesting
that these parameters may be worth further investigation in the context of IUI.
Hence, the interest of this study is to determine whether there is a correlation between
progesterone levels and clinical pregnancy rates in patients undergoing intrauterine
insemination (IUI).
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHI DE CRETEIL | Maud Pasquier, Dr | Contact (sur clinicalTrials) | |||
Critères
Femme
Inclusion Criteria:
- Single women or couples, heterosexual or homosexual, undergoing insemination at the
medically assisted procreation.center
- Aged 18 to 43
- Any indication for IUI in compliance with the Recommendations for Good Practices in
MPA (RBP)
- Blood test on the day of insemination with estradiol, progesterone, LH and hCG
measured as part of routine care
- Single women or couples, heterosexual or homosexual, undergoing insemination at the
medically assisted procreation.center
- Aged 18 to 43
- Any indication for IUI in compliance with the Recommendations for Good Practices in
MPA (RBP)
- Blood test on the day of insemination with estradiol, progesterone, LH and hCG
measured as part of routine care
-Opposition of patients to data collection