Informations générales (source: ClinicalTrials.gov)
Typological Study of Sleep Pathologies During Psoriatic Rheumatism and SAPHO Syndrome: Prospective Study Within the Paris Saint-Joseph Hospital Group" (SleepSO2)
Observational
Fondation Hôpital Saint-Joseph (Voir sur ClinicalTrials)
novembre 2023
novembre 2027
27 juillet 2025
Chronic inflammatory rheumatisms (CIR) are a source of motor disability and various
comorbidities, particularly cardiovascular and metabolic. They also significantly impact
patients' quality of life, including sleep disturbances. Among CIRs, psoriatic arthritis
is a chronic inflammatory arthropathy associated with psoriasis, typically seronegative
for rheumatoid factor. This heterogeneous disease affects peripheral and/or axial joints
and can include extra-articular manifestations such as uveitis and chronic inflammatory
bowel diseases. Its prevalence is estimated between 0.3% and 1% in the general
population.
SAPHO syndrome, similar to psoriatic arthritis, is characterized by specific bone
involvement with a hypertrophic tendency, often affecting the axial skeleton and the
anterior thoracic wall. Pain and inflammation are closely linked to sleep quality,
creating a vicious cycle where pain disrupts sleep and poor sleep amplifies pain
perception. Analgesic treatments, such as opioids, can also cause nocturnal respiratory
pathologies, further disrupting sleep.
Inflammatory processes are regulated by sleep, influencing plasma concentrations of CRP,
IL6, and TNF production. Patients with psoriatic arthritis or SAPHO syndrome share common
risk factors with Obstructive Sleep Apnea Syndrome (OSAS), such as obesity, hypertension,
and metabolic syndrome.
Sleep disorders are common in the general population and likely underdiagnosed in these
patients. Several studies suggest a link between sleep disorders and these rheumatic
conditions, affecting quality of life and exacerbating symptoms. Questionnaires like the
Epworth and Pichot scales provide a more precise evaluation of these symptoms. However,
objective sleep exploration through polysomnography has never been conducted in these
patients.
In summary, CIRs, particularly psoriatic arthritis and SAPHO syndrome, significantly
impact patients' quality of life and sleep, necessitating appropriate evaluation and
management of associated sleep disorders.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| GH PARIS SITE SAINT JOSEPH | Juliette COURTIADE MAHLER | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patient aged 18 years or older
- Patient diagnosed with psoriatic arthritis or SAPHO syndrome and followed at Paris
Saint-Joseph Hospital
- Patient presenting sleep disorders warranting hospitalization for further
-investigation of these disorders
- French-speaking patient
- Patient who does not oppose participation in the research protocol
- Patient aged 18 years or older
- Patient diagnosed with psoriatic arthritis or SAPHO syndrome and followed at Paris
Saint-Joseph Hospital
- Patient presenting sleep disorders warranting hospitalization for further
-investigation of these disorders
- French-speaking patient
- Patient who does not oppose participation in the research protocol
- Patient already followed for a sleep disorder
- Patient who underwent polysomnography in the last 2 years
- End-of-life patient
- Patient under guardianship or curatorship
- Patient deprived of liberty
- Patient under legal protection